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Acute Migraine Clinical Trials in Oklahoma City

Discover potential treatment options for moderate or severe migraine, with or without aura.

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Is Your Daily Life Affected by Migraine Attacks?

You might be eligible for this study.

Migraines affect more than 39 million Americans, disrupting their daily lives with throbbing or pulsating pain often accompanied by nausea, vomiting, and sensitivity to light, sound, or smells. While early intervention remains key, new therapies are being explored to improve migraine management.

At Hightower Clinical, we are currently running clinical trials focused on acute migraine to evaluate the safety and efficacy of a study drug in people as a potential acute migraine treatment option.

Participation in the clinical trial is entirely voluntary and free of charge.

To participate, fill out the form, and a member of our research staff will call you to discuss your eligibility for the Clinical Research Study.

Study Information

Acute Migraine

Study Name	Protocol Number	Sponsor
Acute Migraine	KAL-K304-P001	Kallyope

More about Acute Migraine Clinical Trials

In collaboration with pharmaceutical companies, Hightower Clinical is conducting a research study focused on evaluating an investigational treatment for acute migraine in people with moderate and severe unilateral headaches.

This Phase 2 acute migraine clinical trial aims to determine whether the investigational drug can effectively relieve migraine pain two hours after dosing and reduce other symptoms such as nausea, vomiting, and sensitivity to sound, light, and smell.

Participants will be randomly assigned to one of two groups: one that will receive the investigational drug and another that will receive a placebo.

All study procedures and related treatments, including investigational medication, are provided at no cost, and insurance is not required for participation.

The study doctor will guide you through every step of the clinical trial before you decide to participate and will answer any questions you have about the study treatment.

How are Acute Migraine Clinical Trials Conducted?

Upon agreeing to participate in the acute migraine study, you will be asked to sign an Informed Consent Form that provides comprehensive details about the trial. Our research team will guide you through the study process and explain your role in the trials. We encourage participants to ask any questions they may have before deciding to participate or withdraw from the trial.

Once the consent form is signed and all inquiries are addressed, participants will be randomly assigned to one of two groups: the Control group or the Experimental group.

In the Control group, participants receive a placebo medication, while the Experimental group receives the study drug. This study utilizes a double-blind design, meaning that neither the researcher nor the participant knows which treatment is being administered.

All study-related care is provided at no cost. Expert physicians and healthcare professionals will conduct thorough physical exams and assessments throughout the trial.

Age

18-70 years

Gender

All

Condition

Acute Migraine

Current Status

Recruiting

Acute Migraine and its Complications

Acute migraines are intense, often debilitating headaches that strike suddenly and can last from a few hours to several days. They are usually characterized by throbbing pain on one side of the head, often accompanied by nausea, sensitivity to light and sound, and visual disturbances known as aura. Unlike chronic migraines, which occur frequently, acute migraines are episodic and may be triggered by stress, hormonal changes, certain foods, or lack of sleep.

Complications of Acute Migraines:

Status migrainosus: A migraine attack lasting more than 72 hours.
Medication overuse headaches: Caused by frequent use of pain relief medications.
Migraine with aura–related stroke: Rare, but risk increases especially in women who smoke or use birth control pills.
Persistent aura without infarction: Visual or sensory disturbances that continue even after the headache resolves.
Impaired daily functioning: Disrupts work, school, or personal life due to the severity of symptoms.

Frequently Asked Questions

What is a migraine?

A migraine is a neurological condition marked by intense, throbbing headaches—often on one side of the head—accompanied by symptoms such as nausea, vomiting, and sensitivity to light, sound, or smells.

What causes migraines?

While the exact cause is unknown, migraines are believed to result from abnormal brain activity affecting nerve signals, chemicals, and blood vessels. Common triggers include stress, hormonal changes, certain foods, sleep disturbances, and environmental factors.

How are acute migraines different from chronic migraines?

Acute migraines occur occasionally, with fewer than 15 headache days per month. Chronic migraines happen more frequently—15 or more days per month—and may require long-term management.

What happens in a migraine clinical trial?

Participants are evaluated for eligibility and, if accepted, are randomly assigned to receive either the investigational treatment or a placebo. Throughout the study, they are monitored closely through check-ins, symptom tracking, and health assessments. All study-related care is provided at no cost.

Why should I consider participating in a migraine clinical trial?

By participating, you gain access to potential new treatment options before they become widely available. You’ll also be helping researchers advance migraine care for others while receiving expert medical oversight during the trial.

Contact Us

info@hightowerclinical.com

Call Us Now

(405) 479-8331

Acute Migraine Clinical Trials in Oklahoma City

Enroll Now

Is Your Daily Life Affected by Migraine Attacks?

Acute Migraine

More about Acute Migraine Clinical Trials

How are Acute Migraine Clinical Trials Conducted?

Age

Gender

Condition

Current Status

Acute Migraine and its Complications

Complications of Acute Migraines:

Frequently Asked Questions

What is a migraine?

What causes migraines?

How are acute migraines different from chronic migraines?

What happens in a migraine clinical trial?

Why should I consider participating in a migraine clinical trial?

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