Hightower Clinical in Oklahoma City has successfully completed a variety of clinical studies aimed at advancing treatments for multiple medical conditions. These trials generated valuable insights into the safety and effectiveness of investigational therapies, helping to improve patient care.
Past Studies
- Oncology
- Oncology - Biorepository
- Cardiovascular
- Gastroenterology
- Dermatology
- Pain Management
- Neurology
- Rheumatology
- Endocrinology
- Pulmonology
- Pediatric
- Urology
About Metastatic Breast Cancer Research Study
Metastatic breast cancer, when cancer cells spread beyond the breast, is a challenging diagnosis for millions of women worldwide. While treatment options exist, the fight for a cure continues. At Hightower, we’re dedicated to fueling hope through research.
We have actively managed clinical trials for metastatic breast cancer to evaluate the efficacy and Safety of the investigational drug in patients with estrogen receptor-positive, HER2-negative, locally advanced, or metastatic breast cancer.
Current Status
Not Recruiting
Study Count
01
Study Information
Metastatic Breast Cancer
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Metastatic Breast Cancer | C4891001 | Pfizer |
| WO43571 | Hoffman-La Roche |
About Non-Small Cell Lung Cancer Study
Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of cases. It generally progresses more slowly than small cell lung cancer, often develops in the outer regions of the lungs, and includes various subtypes.
Hightower Clinical conducted a study to evaluate the safety and effectiveness of a bispecific antibody in patients with advanced NSCLC and other solid tumors. The goal was to test the drug as monotherapy or in combination with treatments like Osimertinib or chemotherapy.
Current Status
Not Recruiting
Study Count
01
Study Information
Non-Small Cell Lung Cancer
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Non-Small Cell Lung Cancer | MCLA-129-CL01 | Merus N.V. |
About the APOLLO Study
The Advanced Precision Observational Lung Living Outcomes (APOLLO) study was a pioneering initiative in lung cancer research, designed to advance precision medicine. This innovative study focused on collecting extensive data on the molecular and clinical characteristics of lung cancer patients to help optimize treatment outcomes.
Hightower Clinical’s approach emphasized the inclusion of smokers in the study, acknowledging the critical role smoking plays in lung cancer development and progression. By analyzing diverse patient profiles, including smokers, the study uncovered valuable insights into lung cancer biology and contributed to the development of personalized treatment strategies for individuals battling lung cancer.
Current Status
Not Recruiting
Study Count
01
Study Information
APOLLO – Lung Cancer (Bio repository)
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| APOLLO – Lung Cancer (Bio repository) | P-030101 | PrognomIQ |
About the Lung Cancer Diagnosis Biorepository Clinical Trials
Hightower Clinical partnered with leading pharmaceutical organizations to conduct Lung Cancer Diagnosis Biorepository Clinical Trials in Oklahoma City, OK. This prospective, multi-center, observational study focused on screening blood for potential biomarkers to enable early detection of lung cancer.
The trial enrolled participants aged 50 and older with a smoking history of at least 20 years. By collecting blood samples from high-risk individuals, the study aimed to validate a blood-based test for the early detection of lung cancer, paving the way for more effective diagnostic tools.
Current Status
Not Recruiting
Study Count
01
Study Information
Lung Cancer Diagnosis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Lung Cancer Diagnosis | FRNM-007 | Freenome |
About Malignant Tumors Study
Malignant tumors are aggressive cell growths that invade nearby tissues and can spread to other parts of the body. Unlike benign tumors, which are non-cancerous and remain confined, malignant tumors present serious health risks and often create complex medical challenges. These tumors can develop in various organs, leading to a wide range of symptoms and significantly affecting patient well-being. Early detection through proactive screening is essential, as prompt treatment improves outcomes and enhances survival rates.
Hightower Clinical conducted malignant tumor clinical trials in Oklahoma City aimed to advance cancer care by focusing on biomarker analysis to guide treatment strategies. Participants underwent screenings to assess eligibility, received detailed study insights, and were supported throughout the process by expert healthcare professionals. The trials were offered at no cost to participants, including free study-related care, with compensation provided for time and travel.
Current Status
Not Recruiting
Study Count
01
Study Information
Malignant Tumors- Biorepository (Lighthouse)
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Malignant Tumors- Biorepository (Lighthouse) | GO44296 | Hoffman-La Roche |
About Atrial Fibrillation (AF) Study
Atrial Fibrillation (AF) is a common heart condition characterized by an irregular heart rhythm in the upper chambers (atria). Afib is one of the common types of arrythmias and present symptoms like fatigue, palpitations, difficulty in breathing, and dizziness.
Hightower Clinical conducted a study to evaluate the safety and effectiveness of the Amulet Left Atrial Appendage (LAA) occlusion device as an alternative to NOAC therapy in patients with non-valvular AF at increased risk for stroke. The goal was to provide insight into whether the device can be a safer and more effective long-term option for stroke prevention compared to NOACs.
Current Status
Not Recruiting
Study Count
01
Study Information
Atrial Fibrillation
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Atrial Fibrillation | ABT-CIP-10310 | Abbott |
Contributed to Improved Care for Patients with Heart Failure and CKD
Heart failure occurs when the heart can’t pump blood effectively, leading to symptoms like fatigue, shortness of breath, and swelling. Chronic kidney disease (CKD), a gradual loss of kidney function, often contributes to heart failure by increasing strain on the heart and disrupting fluid and blood pressure balance.
To better understand this connection, Hightower conducted a clinical trial focused on heart failure and impaired kidney function. The study evaluated the effects of a once-daily treatment added to standard care on reducing cardiovascular death and heart failure-related events.
Current Status
Not Recruiting
Study Count
01
Study Information
Heart Failure & Impaired Kidney Function
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Heart Failure & Impaired Kidney Function | BalanceD-HF | AstraZeneca |
About Hypertriglyceridemia Study
Severe Hypertriglyceridemia (SHTG) is a metabolic condition characterized by extremely high triglyceride levels (≥500 mg/dL), posing significant health risks such as pancreatitis and cardiovascular complications. The study explored the efficacy and safety of an investigational treatment designed to lower triglyceride levels and improve patient outcomes. By evaluating fasting serum triglyceride levels over a period of time, this research contributed valuable insights into the potential management of SHTG, bringing us closer to innovative therapeutic solutions.
Current Status
Not Recruiting
Study Count
01
Study Information
Hypertriglyceridemia Research Study
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Hypertriglyceridemia | ENTRUST BIO89-100-231 | 89bio, Inc |
About Peripheral Vascular Thrombosis Study
Peripheral vascular thrombosis refers to the formation of blood clots (thrombosis) in the peripheral blood vessels, including both arteries and veins. Peripheral Vascular Thrombosis encompasses conditions affecting blood flow in the limbs, whether in the arteries (as in PAT) or the veins (as in PVT).
Hightower conducted a study to gather real-world data on the JETi™ Hydrodynamic Thrombectomy System for treating acute and subacute thrombosis in the peripheral vasculature. By monitoring participants for 12 months, the study aimed to evaluate the long-term outcomes and effectiveness of the system in treating both peripheral artery and venous thrombosis.
Current Status
Not Recruiting
Study Count
01
Study Information
Peripheral Vascular Thrombosis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Peripheral Artery Thrombosis | ABT-CIP-10433 | Abbott |
About the Volt AFib Clinical Trial
Hightower Clinical recently completed a study to evaluate a novel system for treating Persistent AFib. Participants were monitored closely to assess the safety and effectiveness of this investigational device. The trial offered free study-related treatment, with the goal of improving outcomes for individuals suffering from symptomatic, recurrent, drug-resistant AFib.
Current Status
Not Recruiting
Study Count
01
Study Information
Volt AFib
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Atrial Fibrillation | ABT-CIP-10514 | Abbott |
About Clostridium difficile infection (CDI)
Clostridium difficile infection (CDI) is a serious bacterial infection affecting the colon, often leading to severe diarrhea and intestinal inflammation. Highly contagious and challenging to manage, CDI significantly impacts patient health and healthcare systems. In the United States alone, CDI accounts for approximately 223,900 cases annually.
While recurrent infections are a major concern, innovative treatments are offering hope for better management. Hightower Clinical Research has been at the forefront, exploring the safety and efficacy of investigational drugs administered via colonoscopy to adults suffering from recurrent CDI.
Current Status
Not Recruiting
Study Count
01
Study Information
Clostridium Difficile
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Clostridium Difficile | 000416 | Ferring |
About Crohn’s Disease Clinical Trials
Crohn’s Disease is a form of Inflammatory Bowel Disease (IBD) impacting over 500,000 Americans. It causes inflammation in the digestive tract and symptoms such as abdominal pain, malnutrition, diarrhea, fatigue, and weight loss. Although it primarily affects intestinal walls, it can involve any part of the digestive system.
Hightower Clinical conducted multiple clinical trials on Crohn’s Disease, evaluating the safety and efficacy of investigational drugs across patients with varying severity levels. Additionally, compared study drugs with those already available in the market. This groundbreaking research aimed to improve treatment outcomes and enhance the quality of life.
Current Status
Not Recruiting
Study Count
09
Study Information
Crohn’s Disease
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Cardiovascular Diseases (CVD) | TAK-279-CD-2001 | Takeda |
| Vedolizumab 4051 CD | Takeda |
Ulcerative Colitis - Inflammatory Bowel Disease
Ulcerative Colitis (UC) is a type of Inflammatory Bowel Disease (IBD) characterized by chronic inflammation in the colon and rectum. The diagnosis of UC primarily relies on colonoscopy results. It is more prevalent than Crohn’s disease, occurring three times more frequently. Ulcerative colitis (UC) affects approximately 1 million individuals (about the population of Delaware) in the United States.
Hightower conducted numerous clinical trials to explore potential treatments and research in Ulcerative Colitis. These trials focused on evaluating the safety and effectiveness of new drugs aimed at reducing the symptoms and colon inflammation of patients with moderate to severe UC and IBDIBD.
Current Status
Not Recruiting
Study Count
07
Study Information
Ulcerative Colitis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Ulcerative Colitis / Inflammatory Bowel Disease (IBD) | ABX464-106 | Abivax |
| 20170104 | Amgen | |
| TAK-279-UC-2001 | Takeda | |
| GS-US-457-6411 | Gilead | |
| Vedolizumab-4054 | Takeda | |
| 000417 | Ferring | |
| C5041047 | Pfizer | |
| M23-784 | Abbvie |
Know About Atopic Dermatitis Research Study
Atopic dermatitis, known as eczema, is a chronic inflammatory skin condition affecting millions worldwide. It causes dry, itchy, and inflamed patches of skin, disrupting sleep, impacting daily activities, and causing significant discomfort. While current treatments offer some relief, they can be ineffective for many.
We actively managed clinical trials for atopic dermatitis. One involved treating patients with moderate to severe atopic dermatitis for whom standard, approved medicated topical and systemic treatment options were inadequate. The second evaluated the efficacy and safety of a subcutaneous investigational drug.
Current Status
Not Recruiting
Study Count
01
Study Information
Atopic Dermatitis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Atopic Dermatitis | 20210145 | Amgen |
Hightower’s Efforts in Basal Cell Carcinoma Prevention
Gorlin syndrome, or nevoid basal cell carcinoma syndrome, is a genetic condition that affects multiple parts of the body and increases the risk of both cancerous and noncancerous tumors. The most common cancer seen in this condition is basal cell carcinoma, a type of skin cancer that often begins to appear in adolescence or early adulthood.
To support patients with Gorlin syndrome, Hightower Clinical conducted a study to evaluate the safety and effectiveness of a topical treatment aimed at preventing new basal cell carcinomas from developing on the face of affected adults.
Past Study Focused on Preventing Facial Tumors in Gorlin Syndrome
Hightower Clinical conducted a study to support individuals with Gorlin syndrome by evaluating the safety and effectiveness of a topical treatment to prevent new facial basal cell carcinomas. This effort aimed to improve long-term skin health and reduce the recurrence of skin cancer in affected adults.
Current Status
Not Recruiting
Study Count
01
Study Information
Gorlin Syndrome
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Gorlin Syndrome | SGT610-01 | Sol-Gel Technologies |
Contributed to Advancing Pediatric Psoriasis Care
Plaque psoriasis (psoriasis vulgaris) is the most common form of psoriasis, affecting around 6.7 million adults. It causes thick, scaly, discolored patches—called plaques—on the skin, commonly appearing on the elbows, knees, back, and scalp. In severe cases, it can affect the face, hands, feet, genitals, and legs. These plaques can be itchy, painful, or feel like burning.
Hightower Clinical conducted a clinical study to evaluate the safety and tolerability of a study drug in children aged 6 to 17 with mild to moderate plaque psoriasis, aiming to expand effective care options for pediatric patients.
Current Status
Not Recruiting
Study Count
01
Study Information
Plaque Psoriasis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Plaque Psoriasis | 20200196 | Amgen |
| PSO-500 | CorEvitas |
Learn About Prurigo Nodularis Clinical Study
Prurigo Nodularis is a chronic skin condition in which itchy nodules or bumps form on the skin. Constant scratching can make the lesions worse, leading to discomfort, pain, and a reduced quality of life. This condition is often difficult to manage, especially when topical treatments do not provide adequate relief.
Hightower Clinical conducted studies to evaluate a potential therapy for Prurigo Nodularis in patients not well controlled by topical treatments. The research aimed to assess the therapy’s effectiveness in reducing symptoms, easing itching, and improving overall quality of life for those living with this challenging condition.
Current Status
Not Recruiting
Study Count
01
Study Information
Prurigo Nodularis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Prurigo Nodularis | 20230053 | Amgen |
Need to Know About Chronic Pain Study
Chronic pain, a constant and often debilitating condition, affects millions worldwide. It can manifest in various forms, from persistent backaches to widespread joint pain, significantly impacting daily life. While treatments exist, managing chronic pain can be a complex challenge.
Hightower has conducted clinical trials for Chronic Pain to evaluate the efficacy, safety, comfort, and compliance with the Nalu Neurostimulation System in adult subjects with chronic leg and back pain.
Current Status
Not Recruiting
Study Count
02
Study Information
Conducted Chronic Pain Trials & Study
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Chronic Pain | MDT22020 | Medtronic |
Evaluated a New Approach for Treating Migraine Pain
Migraines are intense headaches often accompanied by nausea, sensitivity to light and sound, and vision changes. They can significantly disrupt daily activities and lower the quality of life. Acute migraine treatment is essential for reducing the severity and duration of an attack.
To identify more effective treatment options, Hightower Clinical conducted a study evaluating an investigational drug. The study aimed to assess the safety and efficacy of the drug across multiple dose ranges in patients experiencing moderate to severe migraine episodes.
Current Status
Not Recruiting
Study Count
01
Study Information
Acute Migraine
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Acute Migraine | KAL-K304-P001 | Kallyope |
Tested New Solutions for Hard-to-Control Hypertension
Hypertension, or high blood pressure, increases the risk of heart attacks, strokes, and other cardiovascular events—especially in patients with additional risk factors. In many cases, standard medications are not enough to bring blood pressure under control. This highlights the need for innovative treatments that can provide better outcomes.
To address this challenge, Hightower Clinical conducted a clinical study evaluating the safety and efficacy of an investigational drug used alongside current antihypertensive therapies. The goal was to assess its effectiveness in improving blood pressure management in adults at high cardiovascular risk.
Current Status
Not Recruiting
Study Count
01
Study Information
Hypertension
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Hypertension | ALN-AGT01-007 | Alnylam |
About Psoriatic Arthritis Study
Psoriatic Arthritis (PsA) is a chronic inflammatory condition that affects individuals with psoriasis, a skin disease characterized by red, scaly patches. PsA primarily impacts the joints, leading to pain, swelling, and stiffness, and can cause lasting damage if left untreated. Its symptoms can vary in severity, and early diagnosis and treatment are essential to prevent joint damage and improve quality of life.
Hightower Clinical conducted a study to evaluate the efficacy and safety of a possible treatment option for participants with active Psoriatic Arthritis (PsA). The study aimed to provide insights into its effectiveness in reducing symptoms and improving the quality of life for PsA patients.
Current Status
Not Recruiting
Study Count
01
Study Information
Psoriatic Arthritis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Psoriatic Arthritis | IM011-054 | Bristol-Meyer Squibb |
| TILD-19-07 | Sun Pharma |
About ANCA-Associated Vasculitis Clinical Study
ANCA-associated vasculitis is a rare autoimmune disease where the body’s immune system mistakenly attacks blood vessels, causing inflammation and damage to organs like the kidneys, lungs, and nerves.
Hightower Clinical previously conducted a clinical study to explore new ways to manage this condition. The research focused on evaluating the safety and potential benefits of an investigational therapy to help improve future treatment options for patients living with AAV.
Current Status
Not Recruiting
Study Count
01
Study Information
ANCA-Associated Vasculitis
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| ANCA-Associated Vasculitis | 20220159 | Amgen |
Innovative Clinical Study on Systemic Lupus Erythematosus
Systemic Lupus Erythematosus, or SLE, is a chronic autoimmune disease in which the body’s immune system mistakenly attacks its own tissues. This can lead to inflammation and damage to organs such as the skin, joints, kidneys, heart, and lungs. Symptoms often include fatigue, joint pain, skin rashes, and fever, and they can vary widely from person to person.
Hightower Clinical conducted studies to evaluate a new investigational therapy for patients with SLE who had already received standard care. The trials aimed to explore whether this therapy could help improve SLE symptoms and overall quality of life, while also contributing to a better understanding of the disease and potential future treatment options.
Current Status
Not Recruiting
Study Count
01
Study Information
Systemic Lupus Erythematosus
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Systemic Lupus Erythematosus (SLE) | 230LE303 | Biogen |
About Diabetic Peripheral Neuropathy (DPNP)
Diabetic Peripheral Neuropathy (DPNP) is a common complication of diabetes, affecting the nerves in the legs and feet due to prolonged high blood sugar. It causes burning sensations, tingling, stabbing pain, or numbness in the extremities, which can severely impact daily life. While there is no cure, managing blood sugar and exploring innovative treatments can alleviate symptoms and improve quality of life.
Current Status
Not Recruiting
Study Count
01
Study Information
Peripheral Neuropathic Pain
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Peripheral Neuropathic Pain | LX9211.1-204-DPN | Lexicon |
Eosinophilic Asthma Study
Eosinophilic asthma is a severe form of asthma caused by elevated levels of eosinophils, a type of white blood cell that leads to airway inflammation. This inflammation can cause persistent symptoms like wheezing, coughing, chest tightness, and shortness of breath, significantly affecting quality of life. The clinical trial investigated the safety, tolerability, and efficacy of an experimental medication designed to manage the symptoms and improve lung function and find better treatments for eosinophilic asthma.
Current Status
Not Recruiting
Study Count
02
Study Information
Eosinophilic Asthma
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Eosinophilic Asthma | AR-DEX-22-02 | Areteia Therapeutics |
| AR-DEX-22-03 | Areteia Therapeutics |
About Infant Development
Infant development is a crucial phase marked by rapid physical and cognitive changes. Healthy growth during the first few months of life lays the foundation for a child’s long-term well-being. Nutrition plays a key role, with essential vitamins and minerals like iron promoting optimal growth, brain development, and immune function. Monitoring infants’ growth helps ensure they are meeting developmental milestones and thriving during these formative months.
This 16-week study focused on evaluating the growth and tolerance of healthy term infants fed iron-fortified formula. Conducted across multiple centers, the trial followed FDA-established guidelines to assess whether the formula supports normal growth and development. The findings aimed to contribute valuable insights into infant nutrition and growth standards.
Current Status
Not Recruiting
Study Count
01
Study Information
Atrial Fibrillation
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Infant Development | BubsGMS_2023 | Aussie Bubs, inc |
About the Urinary Tract Infection Research Study
This phase 2, double-blind, randomized Urinary Tract Infection Research Study aimed to evaluate the effectiveness of a new treatment in combination with antibiotics. The study focused on reducing the impact of drug-resistant E. coli infections in patients with active acute uncomplicated UTIs through innovative therapies.
In Part 1, the study assessed optimal dosing for the investigational drug among 30 participants, focusing on pharmacokinetics and safety. Part 2 involved randomly assigning participants to receive either the study drug + antibiotics or placebo + antibiotics, to evaluate the treatment’s efficacy and safety.
Current Status
Not Recruiting
Study Count
01
Study Information
Urinary Tract Infection – UTI
| Study Name | Protocol Number | Sponsor |
|---|---|---|
| Urinary Tract Infection | LBx-2001 | Locus Bioscience |
