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Knee Osteoarthritis Clinical Trial in Oklahoma City

Clinical trials on joint health, where your participation could support future osteoarthritis treatments.

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Does Every Step Feel Like a Mountain Hike? Stop Letting Knee OA Steal Your Mobility.

Discover a research opportunity for Knee Osteoarthritis at Hightower Clinical.

Knee osteoarthritis (OA) is one of the most common joint conditions among adults and often leads to chronic pain, stiffness, and limited mobility. As the protective cartilage in the knee wears down, daily movement becomes increasingly difficult, affecting quality of life.

Hightower Clinical is currently enrolling participants for a research study evaluating an investigational injectable therapy that may help improve knee function and slow the progression of osteoarthritis. This study is designed for adults with mild to moderate osteoarthritis in one knee.

*Participation in the Clinical Trial is completely free of cost and is your choice.

*To participate, fill out the form, and someone from our research staff will call you to determine your eligibility for the Clinical Research Study.

Study Information

Knee Osteoarthritis Clinical Trial

Study NameProtocol NumberSponsor
Knee OA Clinical Trial

TPX-100-6

OrthoTrophix, Inc.

About the Research Study for Chronic Knee Arthritis

This clinical trial is designed to assess the safety and effectiveness of an investigational peptide injected directly into the affected knee joint. Researchers believe this therapy may help improve the condition of the bone and cartilage involved in OA, which could support better knee function over time.

Participants will receive either investigational peptide or a placebo through a series of four weekly injections. The study uses a double-blind design, meaning neither you nor the study team will know which treatment you are receiving. Throughout the study, imaging and assessments; such as MRI scans, mobility evaluations, and symptom questionnaires, will help researchers understand how the therapy affects knee structure and function.

By joining this trial, you are contributing to research aimed at finding better, non-surgical options for people living with knee osteoarthritis.

*All study procedures and study-related treatment, including the investigational drug, are free of cost, and insurance is not required to participate.

*The study doctor will take you through every step of the Clinical Trial before you decide to participate and will answer any questions you have about the study treatment.

Osteoarthritis of the Knee Research Study: What to Expect?

If you decide to participate, the first step is signing an Informed Consent Form. This document explains the study details, procedures, potential risks, and your rights as a participant. Our research team will guide you through every step and answer any questions you may have.

Once consent is provided, you’ll undergo a screening visit that includes medical evaluations and an MRI of your knee. This MRI will determine eligibility based on specific bone-shape measurements used in osteoarthritis research.

If eligible, you will be randomly assigned to either the investigational treatment group or the placebo group. All injections are administered by trained professionals using imaging guidance to ensure accuracy and safety.

You will attend several follow-up appointments for approximately one year. These visits allow our team to monitor your symptoms, evaluate your knee structure with MRI, and track changes in mobility and comfort levels.

* Study-related care is offered at no charge. Expert physicians and healthcare professionals conduct thorough physical exams and assessments.

Age

50 - 80 years and older

Gender

Male & Female

Condition

Knee Osteoarthritis

Current Status

Recruiting

What Happens in Knee Osteoarthritis?

Osteoarthritis of the knee occurs when the protective cartilage that cushions the ends of your bones gradually breaks down. As this cartilage wears away, the bones begin to rub against each other, causing pain, swelling, and stiffness. Over time, the joint becomes less flexible, making everyday activities harder to manage.

Complications

  • Joint Damage: Continued cartilage loss can lead to significant wear-and-tear on the bones, causing deformity or permanent joint changes.
  • Reduced Mobility: As the knee becomes stiffer and more painful, walking, climbing stairs, and standing for long periods become difficult.
  • Bone Spurs: Extra bone may form around the joint, causing more discomfort and limiting movement.
  • Chronic Pain: Persistent inflammation and bone-on-bone friction can lead to long-term knee pain that affects quality of life.

Symptoms & Challenges

  • Knee Pain: Pain during movement or after long periods of inactivity is often the first noticeable symptom.
  • Stiffness: The knee may feel tight, especially in the morning or after sitting for a while.
  • Swelling or Tenderness: Inflammation around the knee joint can cause visible swelling or sensitivity to touch.
  • Grinding or Popping: You may notice a crackling or grinding sound when bending or straightening the knee.
  • Limited Range of Motion: As the condition progresses, bending or fully extending the knee can become difficult.

Frequently Asked Questions

What happens during a knee osteoarthritis clinical trial?

Participants receive either an investigational treatment or a placebo through four weekly knee injections. You’ll attend regular follow-up visits for imaging, mobility assessments, and safety checks to monitor changes in knee structure and symptoms.

What if I have other joint conditions? Can I still participate?

Eligibility depends on your medical history, knee imaging results, and other health factors. A screening visit, including an MRI, helps determine whether this study is a safe fit for you.

Why participate in a knee osteoarthritis clinical trial?

You may gain access to a potential new treatment option and contribute to research that could improve future therapies for osteoarthritis. All study-related care is provided at no cost, and insurance is not required.

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